- Isotype selection
- Fc silencing
- ADCC and CDC enhancement
- Antibody fragments
- Sequence design
- Heavy chain heterodimerization
- Light chain shuffling
- Fc fusion
- Albumin fusion
- Albumin binding domains
- Polymers
- Hybridoma sequencing
- 5' RACE, PCR and NGS
- De novo protein sequencing
- N or C terminal fusions
- Homodimeric or heterodimeric fusions
- High yielding expression
- HEK293 and CHO
- Chemical transfection
- Electroporation
- Over 100 mAbs humanized
- Humanization strategies
- CDR annotation
- IP considerations
- Choice of delivery platform
- Design of related molecules
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